PUBLICATIONS

As an Assistant Professor at Penn State

Rios, K.T. & Lindner S.E.

“Protein-RNA Interactions Important for Plasmodium Transmission.”
PLoS Pathogens. 2019 Dec 26; 15(12):e1008095. doi: 10.1371/journal/ppat.1008095. Invited Review.

 

Lindner, S.E.*, #, Swearingen, K.E.*, Shears, M., Walker, M.P., Vrana, E.N., Hart, K.J., Minns, A.M., Sinnis, P., Moritz, R.L., & Kappe, S.H.I. #

“Transcriptomics and proteomics reveal two waves of translational repression during the maturation of malaria parasite sporozoites.”

Nature Communications. 2019 Oct 31; 10(1):4964. doi: 10.1038/s42467-019-12936-6.

(* equal contribution, # joint supervision/co-corresponding authors)

 

Lee, M., Lindner, S.E., Marco-Rubio, J.J., & Llinás, M.

“Cutting back malaria: CRISPR/Cas9 genome editing of Plasmodium.”

Briefings in Functional Genomics. 2019 Jul 29. pii:elz012. 1-9. doi: 10.1093/bfgp/elz012. Invited Review.

 

Vivax Sporozoite Consortium (Alphabetical): Ansell, B., Charnaud, S., Duffy, M., Emery-Corbin, S.J., Flannery, E., Jex, A., Kappe, S.H., Koepfli, C., Mikolajczak, S., Muller, I., Lerch, A., Lindner, S.E., Merrienne, N., Patrapuvich, R., Petter, M., Sattabongkot, J., Smith, J., and Swearingen, K.E..

“Transcriptome and histone epigenome of Plasmodium vivax salivary-gland sporozoites point to tight regulatory control and mechanisms for liver-stage differentiation in relapsing malaria.”

International Journal for Parasitology. 2019 Jun; 49(8):501-513 doi: 10.1016/j.ijpara.2019.02.007.

 

Walker M.P., & Lindner, S.E.

“Ribozyme-Mediated, Multiplex CRISPR Gene Editing and CRISPR interference (CRISPRi) in rodent-infectious Plasmodium yoelii.”

Journal of Biological Chemistry. 2019 Jun 14; 294(24):9555-9566. doi: 10.1074/jbc.RA118.007121

**Featured as one of the Top 50 most viewed JBC papers in May and June 2019.

 

Hart, K.J., Oberstaller, J., Walker, M.P., Minns, A.M., Kennedy, M.F., Padykula, I., Adams, J.H., & Lindner, S.E.

Plasmodium male gametocyte development and transmission are critically regulated by the two putative deadenylases of the CAF1/CCR4/NOT Complex.”

PLoS Pathogens. 2019 Jan 31; 15(1):e1007164. 1-28.

**Selected as the week’s Featured Research Article.

 

Swearingen, K.E. & Lindner S.E.

Plasmodium Parasites Viewed Through Proteomics”

Trends in Parasitology. 2018 Nov; 37(11): 945-960. doi: 10.1016/j.pt.2018.08.003. Invited Review.
**Featured as the Cover Image/Publication for November 2018.

 

Bennink, S., von Bohl, A., Ngwa, C., Henschel, L., Kuehn, A., Pilch, N., Weibbach, T., Rosinksi, A.N., Scheuermayer, M., Repnik, U., Przyborski, J.M., Minns, A.M., Orchard, L.M., Lindner, S.E., Griffiths, G., Llinás , M., & Pradel, G.

“A seven-helix protein constitutes stress granules crucial for regulating translation during human-to-mosquito transmission of Plasmodium falciparum.”

PLoS Pathogens. 2018 Aug 22; 14(8):e1007249. 1-36.

 

Liang, X., Hart, K.J., Gang, D., Siddiqui, F.A., Sebastian, A., Li, X., Albert, I., Miao, J., Lindner, S.E., & Cui, L.

“Puf3 participates in ribosomal biogenesis in malaria parasites.”

Journal of Cell Science. 2018 Mar 26; 131(6). doi: 1.1242/jcs.212597.

 

Hahn, W.O., Butler, N.S., Lindner, S.E., Akilesh, H.M., Sather, D.N., Kappe, S.H.I., Hamerman, J.A., Gale Jr., M., Liles, W. C., & Pepper, M.

“cGAS-mediated control of blood-stage malaria promotes Plasmodium-specific germinal center responses.”

JCI Insight. 2018 Jan 25;3(2). 1-19. doi: 10.1172/jci.inisight.94132

 

Minns, A.M., Hart, K.J., Subramanian, S., Hafenstein, S., & Lindner S.E.

“Nuclear, Cytosolic, and Surface Localized Poly(A)-Binding Proteins of Plasmodium yoelii.”

mSphere. 2018 Jan 10; 3(1). 1-13. pii:e00435-17. doi: 10.1128/mSphere.00435-17.

 

Zander, R.A., Vijay, R., Pack, A.D., Guthmiller, J.J., Graham, A.C., Lindner, S.E., Vaughan, A.M., Kappe, S.H., & Butler N.S.

“Th1-like Plasmodium-specific memory CD4+ T cells support humoral immunity.”

Cell Reports. 2017 Nov 14; 21(7): 1839-1852. doi: 10.1016/j.celrep.2017.10.077

Munoz, E. E., Hart, K. J., Walker, M. P., Kennedy, M. F., Shipley, M. M., & Lindner, S.E.

“ALBA4 modulates its stage-specific interactions and specific mRNA fates during Plasmodium yoelii growth and transmission.”
Molecular Microbiology. 2017 Oct; 106(2):266-284. doi: 10.1111/mmi.13762

 

Swearingen, K. E., Lindner, S.E., Flannery, E., Vaughan A.M., Patrapuvich, R., Kopfli, C., Muller, I., Jex, A., Moritz, R.L., Kappe, S.H.I., Sattabongkot, J. & Mikolajczak, S.

“Proteogenomic analysis of the total and surface-exposed proteomes of Plasmodium vivax salivary gland sporozoites.”
PLoS Neglected Tropical Diseases. 2017 Jul 31; 11(7):e0005791. 1-36. doi: 10.1371/journal/pntd.005791.

 

El-Manzalawy, Y., Munoz, E.M., Lindner, S.E.*, & Honavar, V.*

“PlasmoSEP: Predicting Surface Exposed Proteins on the Malaria Parasite Using Semi-supervised, Self-training, and Expert-annotated Data.”
Proteomics. 2016 Dec; 16(23):2967-2976.

(* joint supervision/co-corresponding authors)

 

Huang, W., Hulverson, M.A., Zhang, Z., Choi, R., Hart, K.J., Kennedy, M., Subba Rao Vidadala, R.,  Maly, D.J., Van Voorhis, W.C., Lindner, S.E., Fan, E., & Ojo, K.K.

“5-Aminopyrazole-4-carboxamide analogues are selective inhibitors of Plasmodium falciparum microgametocyte exflagellation and potential malaria transmission blocking agents.”

Bioorganic & Medicinal Chemistry Letters. 2016 Nov 15; 26 (22):5487-5491. doi: 10.1016/j.bmcl.2016.10.014

 

Swearingen, K.E.*, Lindner, S.E.*, Shi, L., Shears, M.J., Harupa, A., Hopp, C.S., Vaughan, A.M., Springer, T.A., Moritz, R.L., Kappe, S.H., & Sinnis, P.

“Interrogating the Plasmodium Sporozoite Surface: Identification of Surface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP by Mass Spectrometry-Based Proteomics.”

PLoS Pathogens. 2016 Apr 29; 12(4):e1005606. 1-32. doi: 10.1371/journal.ppat.1005606.
(* equal contribution)
**Recognized as one of the “Top 50 Most Downloaded” articles of the year for PLoS Pathogens.

 

Reddy, B.P.N., Shrestha, S., Hart, K.J., Liang, X., Kemirembe, K., Cui, L., & Lindner, S.E.
“A bioinformatic survey of RNA-binding proteins in Plasmodium.”

BMC Genomics. 2015 Nov 2; 16:890. 1-26. doi: 10.1186/s12864-015-2092-1
 

Mikolajczak, S.A.*, Vaughan, A.V.*, Kangwanrangsan, N., Yimamnuaychok, N., Rezakhani, N., Fishbauger, M., Lakshmanan, V., Singh, N., Kaushansky, A., Baldwin, M., Lindner, S.E., Adams, J.H., Prachumsri, J., & Kappe, S.H.

Plasmodium vivax liver stage development and hypnozoite persistence in human liver-chimeric mice.”
Cell Host & Microbe. 2015 Apr 8; 17(4): 526-35. doi: 10.1016/j.chom.2015.02.011. (* equal contribution)

 

Cui, L., Lindner, S., & Miao, J.

“Translational regulation during stage transitions in malaria parasites.”

The Annals of the New York Academy of Sciences. 2015 Apr; 1342:1-9 doi: 10.1111/nyas.12573. Invited Review.

As a Post-Doc/Staff Scientist at Seattle Biomedical Research Institute

Harupa, A., Sack, B., Lakshmanan, V., Arang, N., Douglass, A., Oliver, B., Stuart, A., Sather, D.N., Lindner, S.E., Hybiske, K., Torii, M., & Kappe, S.H.I.

“SSP3 is a novel Plasmodium yoelii sporozoite surface protein with a role in gliding motility.”

Infection and Immunity. 2014 Nov; 82(11): 4643-4653. doi: 10.1128/IAI.01800-14.

 

Lindner, S.E., Sartain, M.J., Hayes, K., Harupa, A., Moritz, R.L., Kappe, S.H.I. & Vaughan, A.M.

“Enzymes involved in plastid-targeted phosphatidic acid synthesis are essential for Plasmodium yoelii liver-stage development.”

Molecular Microbiology. 2014 Feb; 91(4): 679-693. doi: 10.1111/mmi.12485
**Featured as the Cover Image/Publication

Mailu, B.M., Ramasamay, G., Mudeppa, D.G., Li, L., Lindner, S.E., Peterson, M.J., DeRocher, A.E., Kappe, S.H.I., Rathod, P.K., & Gardner, M.J.

"A nondiscriminating glutamyl-tRNA synthetase in the Plasmodium apicoplast: the first enzyme in an indirect aminoacylation pathway.”

Journal of Biological Chemistry. 2013 Nov 8; 288(45):32539-52. doi: 10.1074/jbc.M113.507467

 

Pei, Y. *, Miller, J.L. *, Lindner, S.E., Vaughan, A.M., Torii, M., & Kappe, S.H.I.

Plasmodium yoelii inhibitor of cysteine proteases is exported to exomembrane structures and interacts with yoelipain-2 during asexual blood-stage development.”

Cellular Microbiology. 2013 Sep; 15(9):1508-1526. doi: 10.1111/cmi.12124.
(* equal contribution)

 

Lindner, S.E., Mikolajczak, S.A., Vaughan, A.M., Moon, W., Joyce, B.R., Sullivan, W.J., & Kappe, S.H.I.

“Perturbations of Plasmodium Puf2 expression and RNA-seq of Puf2-deficient sporozoites reveal a critical role in maintaining RNA homeostasis and parasite transmissibility.”
Cellular Microbiology. 2013 Jul; 15(7):1266-1283. doi: 10.1111/cmi.12116.

 

Lindner, S.E. *, Swearingen, K.E. *, Harupa, A., Vaughan, A.M., Sinnis, P., Moritz, R.L., & Kappe, S.H.I.

“Total and putative surface proteomics of malaria parasite salivary gland sporozoites.”

Molecular and Cellular Proteomics. 2013 May; 12(5): 1127-1143. doi:10.1074/mcp.M112.024505
(* equal contribution)

 

Kennedy, M., Fishbaugher, M.E., Vaughan, A.M., Patrapuvich, R., Boonhok, R., Yimamnuaychok, N., Rezakhani, N., Metzger, P., Ponpuak, M., Sattabongkot, J., Kappe, S.H., Hume, J.C.C., & Lindner, S.E. 

“A rapid and scalable density gradient purification method for Plasmodium sporozoites.”

Malaria Journal. 2012 Dec 17; 11:421. 1-10. doi: 10.1186/1475-2875-11-421.

 

Vaughan, A.M., Mikolajczak, S. A., Camargo, N., Lakshmanan, V., Kennedy, M., Lindner, S.E., Miller, J.L., & Kappe, S.H.

“A transgenic Plasmodium falciparum NF54 strain that expresses GFP-luciferase throughout the parasite life cycle.”

Molecular and Biochemical Parasitology. 2012 Dec;186(2): 143-147. doi: 10.1016/j.molbiopara.2012.10.004.

 

Lindner, S.E. *, Miller, J.L. *, & Kappe, S.H.

“Malaria parasite pre-erythrocytic infection: preparation meets opportunity.”

Cellular Microbiology. 2012 Mar; 14(3): 316-324. doi: 10.1111/j.1462-5822.2011.01734.x.
(* equal contribution) Invited Review.

 

Lindner, S.E., Llinás, M., Keck, J.L., & Kappe, S.H.

“The primase domain of PfPrex is a proteolytically matured, essential enzyme of the apicoplast.”

Molecular and Biochemical Parasitology. 2011 Dec; 180(2): 69-75. doi: 10.1016/j.molbiopara.2011.08.002.

 

Aly, A.S.I, Lindner, S.E., MacKellar, D.C., Peng, X., & Kappe, S.H.

“SAP1 is a critical post-transcriptional regulator of infectivity in malaria parasite sporozoite stages.”

Molecular Microbiology. 2011 Feb; 79(4): 929-939. doi: 10.1111/j.1365-2958.2010.07497.x.

As a Post-Doc at the University of Wisconsin

Kolonko, E.M, Albaugh, B.N., Lindner, S.E., Chen, Y, Satyshur, K.A., Keck, J.L., Kaufman, P.D., & Denu, J.M.

“Catalytic activation of histone acetyltransferase Rtt109 by a histone chaperone.”

Proceedings of the National Academy of Sciences USA. 2010 Nov 23; 107(47): 20275-20280. doi: 10.1073/pnas.1009860107.

 

Lindner, S.E., De Silva, E., Keck, J.L. & Llinás, M.

“Structural determinants of DNA binding by a P. falciparum ApiAP2 transcriptional regulator.”

Journal of Molecular Biology. 2010 Jan 22; 395(3): 558-567. doi: 10.1016/j.jmb.2009.11.004.

Berndsen, C.E., Tsubota, T., Lindner, S.E., Lee, S., Holton, J.M., Kaufman, P.D., Keck, J.L., & Denu, J.M.

“Molecular functions of the histone acetyltransferase chaperone complex Rtt109-Vps75.”
Nature Structural and Molecular Biology. 2008 Sep; 15(9): 948-956.

As a Ph.D. Student at the University of Wisconsin

Lindner, S.E., Zeller, K., Schepers, A., & Sugden, B.

“The affinity of EBNA1 for its origin of DNA synthesis is a determinant of the origin’s replicative efficiency.”

Journal of Virology. 2008 Jun; 82(12): 5693-5702. doi: 10.1128/JVI.00332-08.

 

Lindner, S.E. & Sugden, B.

“The plasmid replicon of Epstein-Bar Virus: mechanistic insights into efficient, licensed, extrachromosomal replication in human cells.”

Plasmid. 2007 Jul; 58(1): 1-12. Invited Review.

 

Wang, J. *, Lindner, S.E. *, Leight, E.R., & Sugden, B. “Essential elements of a licensed, mammalian plasmid origin of DNA synthesis.”

Molecular and Cellular Biology. 2006 Feb; 26(3): 1124-1134.

(* equal contribution)

© 2020 by Scott E. Lindner, Ph.D.